Time course of cellular enzyme release in dog heart injury.

Time course of cellular enzyme release in dog heart injury.

The transport time of enzyme from heart to plasma was studied in two experimental models. First, the enzyme alanine aminotransferase was slowly infused into the left ventricular wall in open-chest dogs. The half-life for the washout of alanine aminotransferase activity into plasma was 20 +/- 4 minutes (mean +/- SEM, n = 8) and was not different in ischemic and normally perfused tissue. From mea...

Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

Release of adenosine in reactive hyperemia of the dog heart.

RUBQRAFAEL, ROBERT M. BERNE, AND MAKOTO KATORI. cardial hypoxia were imposed in these studies in order to liberate quantities of adenosine which could be detected by the techniques then available. However, improvements in techniques have made possible the detection of extrelnely small amounts of adenosine in coronary venous blood. The present study was undertaken to determine whether adenosine ...

Retracted: Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

P49: The Role of Extra Cellular Matrix in Brain Injury

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